cell cycle checkpoint

Cell Cycle Checkpoint Control and Tumorigenesis

细胞周期关卡调控与细胞癌变

BACKGROUND& OBJECTIVE: ATM gene is a member of PI-3K kinase family. ATM protein is capable of controlling DNA repair process and cell cycle checkpoint.

背景与目的：ATM基因属于PI-3K激酶家族成员，其编码蛋白具有调控DNA修复过程和调整细胞周期关卡的功能。

It is considered that there is a cell cycle checkpoint determinant which is postulated to be able to arrest the irradiated cells in G1 phase to allow them to repair damage before they undergo DNA synthesis.

一般认为细胞周期中有检点因子，并假定它能捕获G1期受照细胞使之在进入DNA合成期前修复损伤。

Functions of Polo-like Kinase 1 in Cell Cycle and Cell Cycle Checkpoint

Polo样激酶1在细胞周期及细胞周期监测点中的功能

Conclusion: Dysregulated cell cycle checkpoint in Tat-expressing cells can provide new information for understanding the radiation responsiveness of AIDS patients with cancer to radiotherapy.

结论：HIV-1Tat蛋白导致G2/M检验点功能紊乱，将影响细胞的辐射敏感性，本研究为了解AIDS合并肿瘤患者对放射治疗敏感性提供了重要实验数据。

The serum-responsive element in the PCNA 5 ′ promoter, the transcriptional regulation of PCNA gene in the cell cycle DNA damage checkpoint, were elucidated in detail.

538~+60区域启动子的调控做了比较全面的分析，着重研究了5′启动子中的血清刺激应答元件以及PCNA在细胞周期DNA损伤检查点（checkpoint）机制中的转录调控。

Micro Mechanisms of Cell Cycle Regulation and Checkpoint Control

细胞周期调控的分子机制与关卡调控

Several factors, such as defects in chromosome segregation and DNA damage response, failure of cell cycle checkpoint, telomere dysfunction, may cause chromosomal instability.

多种细胞机制功能障碍将导致染色体不稳定性，包括染色体分离、DNA损伤反应、细胞周期检查点、端粒功能等。

This study was designed to set up and evaluate a new method, Cyclins/ DNA multiparameter FCM based on the model of late G1 phase ( G1L) checkpoint, for analyzing cell cycle checkpoint.

本研究以晚G1期检测点为模式，建立一种新的细胞周期检测点分析方法&Cyclins/DNA双参数流式细胞术，并评价应用该方法进行细胞周期检测点分析的可行性和优越性。

Traditional chemotherapeutics such as DR treatment can activate the cell cycle checkpoint.

传统化疗药正定霉素（DR）处理可使其细胞周期检查点蛋白上调。

1-cell mouse embryos in vitro fertilized with DNA-damaged sperm induced by oxidative stress activates the of G2/ M cell cycle checkpoint to delay the progress of the first mitotic cell cycle.

氧化应激性DNA损伤精子体外受精后胚胎细胞在第一次有丝分裂细胞周期启动了G2/M检查点。

But so far there have been few studies investigating the role of DNA damage and repair system or cell cycle checkpoint signal pathways in embryonic development.

目前胚胎发育过程中损伤修复系统以及细胞周期检查点系统的研究不多，确切作用机制尚不清楚。

As an important tumor repression gene, p53 could induce apoptosis after DNA damage in mammal cells and involve in DNA repair and cell cycle checkpoint.

作为一个重要的抑癌基因，p53同时也能使哺乳动物细胞DNA损伤后被诱导凋亡，或引起细胞周期阻滞并进行DNA修复等。

The different micro mechanisms and macro behaviors occured in the different regions. Micro Mechanisms of Cell Cycle Regulation and Checkpoint Control

对于管材不同区段的宏观行为和微观机理的研究发现，不同区段的变形特点不同。细胞周期调控的分子机制与关卡调控

Roles of NF κ B in G 1/ S Cell Cycle Checkpoint and Apoptosis Induced by HCPT in Human Breast Carcinoma Cells

NFκB在羟基喜树碱诱导乳腺癌细胞凋亡和细胞周期阻滞中的作用机制研究

Cell cycle checkpoint is a vital mechanism to maintain the genomic stability of the cell.

细胞周期检控点是维持细胞基因组稳定性的一个重要机制，主要包括DNA损伤检控点、DNA复制检控点和纺锤体组装检控点。

ATM protein play a critical role in the signal transduction of cell cycle checkpoint, the repair of damaged DNA and the apoptosis.

ATM蛋白主要参与细胞周期关卡，DNA损伤修复和凋亡等一系列重要的细胞功能的信号传导，并起到枢纽作用。